David Mangelsdorf, a world-renowned scientist and beloved professor at UT Southwestern Medical Center in Dallas, Texas, has passed away, leaving behind an extraordinary legacy in biomedical science and education. His death has deeply impacted the academic and research communities, both in the U.S. and internationally.
Dr. Mangelsdorf was widely recognized for his pioneering contributions to the field of nuclear receptor biology. His collaborative discoveries of orphan nuclear receptors transformed the understanding of metabolism and disease, paving the way for new insights into conditions such as diabetes, obesity, and cholesterol disorders. As Chair of the Department of Pharmacology at UT Southwestern, he led with vision and integrity, helping establish the department as a leader in biomedical research.
Beyond his groundbreaking work, Dr. Mangelsdorf was celebrated as a mentor and role model. Known for his humility, generosity, and commitment to scientific excellence, he nurtured generations of researchers, many of whom have gone on to lead their own successful careers. Colleagues and students alike admired his collaborative spirit and passion for discovery.
In addition to his professional achievements, Dr. Mangelsdorf was a cherished figure within the Dallas community. His influence reached far beyond the lab, marked by a personal warmth and quiet dedication that left a lasting impression on everyone he encountered.
Dr. Mangelsdorf is survived by his family, friends, and a vast network of colleagues and students who continue to be inspired by his life and work. UT Southwestern Medical Center will host a memorial service to honor his profound contributions to science and his enduring impact on the lives of so many.
His legacy will live on in the research he advanced, the people he mentored, and the future breakthroughs his work made possible.